Programme

PROGRAMME

Mercredi 14 octobre 2015

17h30-19h  Enregistrement et cocktail de bienvenue

19h             Dîner

20h30 – 20h45            Ouverture du congrès : 

Véronique Maguer–Satta (Présidente du CHO) 

20h45 – 21h30             Tariq ENVER (UCL, London, UK) 

Keynote lecture: “Origins and Evolution of Childhood Leukaemia” 

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Jeudi 15/10/2015, 9h – 11h45. Session 2 

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Modérateurs:            Thierry Jaffredo – Françoise Pflumio  

8h30 – 9h15             Erika Brunet (Musée N^al D’Histoire, Paris) 

Cancer translocations using genome editing methods (CRISPR/Cas9) to understand oncogenesis 

9h15 – 9h30             Bérengère DeLaval (CIML, Inserm U1104, CNRS UMR7280, Marseille) 

Differential proliferative response and early myeloid commitment of HSC depending on previous infection history 

9h30 – 9h45             Marie-Laure Arcangeli (CEA-iRCM-INSERM U967, Fontenay-aux-Roses) 

Effects of Low doses of ionizing radiations on human Hematopoietic Stem cell functions 

9h45 – 10h            Présentation rapide des posters. Session I 

10h – 10h30             Pause 

10h30 - 10h45             Alessandro Donada (INSERM U1170, IGR, Villejuif) 

Modeling of the pre-leukemic state in ANKRD26-thrombocytopenia by induced pluripotent stem cells 

10h45 – 11h             Romain Aucagne (IRIC, Montréal, QC, Canada) 

Centrosomal localization of BMI1 reveals a key role for Polycomb proteins in coordinating centrosome duplication and cell cycle progression 

11h00 - 11h45             Roger Patient (Radcliffe Department of Medicine, Oxford, UK). 

Leukaemia-affiliated transcription factors, under the control of embryonic signals, drive HSC development 

11h45             Déjeuner 

Jeudi 15/10/2015, 15h – 18h. Session 3 

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Modérateurs:            Michèle Souyri – Pierre Lutz

15h - 15h45             Thierry Jaffredo (UMR7622, UPMC, Paris, France). 

Hemogenic endothelium during development and beyond 

15h45 – 16h             Carine Halfon-Domenech (CNRS UMR 7622, INSERM U1156, UPMC PARIS6) 

Exhaustion in myeloid lineage and very early defect in HSPC pool: an embryonic origin of Fanconi haematological disorders 

16h - 16h15             Michèle Crozatier (CBD /UMR 5547 TOULOUSE III) 

Vascular control of the Drosophila haematopoietic niche: role of Slit/Robo signalling 

16h15 -16h30             Présentation rapide des posters. Session II 

16h30 – 17h            Pause

17h – 17h15             Marielle Balzano-Foucher (CRCM - Inserm U1068 - CNRS UMR 7258 Marseille) 

Hematopoietic Stem Cell and early B cell differentiation programs depend on a unique multispecific perivascular niche 

17h15 – 17h30             Grégoire Stik (CNRS UMR 7622, Inserm 1156, IBPS, UPMC Paris 6) 

Roles of Exosomes in the Hematopoietic Stem Cell-Supporting Capacity of Stromal Cells 

17h30- 17h45              Elodie Grockowiak (Inserm U1052-CNRS UMR5286, Lyon) 

BMP signalling deregulations persist in CML resistant patients under treatments and contribute to LSC persistence independently of BCR-ABL 

17h45 – 18h30             Daniela Krause (Georg Speyer Haus, Frankfurt, Germany). 

A hostel for the hostile:  Characterising and therapeutic targeting of the leukaemic stem cell niche

18h 30            Apéritif – Poster session 

20h30             Dîner 

Vendredi 16/10/2015, 9h – 11h45. Session 4 

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Modérateurs :             Michael Sieweke – Frédéric Mazurier 

9h - 9h45             Eric Solary (U1170 INSERM, IGR, Villejuif, France) 

Chronic myelomonocytic leukemia: strategies to improve diagnosis and care 

9h45 - 10h             Kevin Rouault-Pierre (Haematopoietic Stem Cell Lab, London) 

Myelodysplastic Syndrome-Initiating Cells can propagate from Multipotent Progenitorcompartment 

10h - 10h15             Laetitia Saint Paul (Inserm U866, Dijon) 

Localization of the CD45 phosphatase within lipid rafts is crucial for AML maintenance 

10h15 - 10h45             Pause 

10h45 – 11h             Florence Zylberstein (U1163/U1052, Lyon) 

Vitamin D receptor controls stemness in acute myeloid leukemia 

11h – 11h15            Cathy Ignacimouttou (INSERM U1170, IGR, Villejuif) 

Deregulation of both ETO2 and GLIS2 functions in acute megakaryoblastic leukemia 

11h15- 12h            Ruud Delwel (Erasmus, Rotterdam, Holland) 

Molecular breakdown of acute myeloid leukemia with aberrant expression of EVI1 and GATA2 

12h            Déjeuner 

13h30 – 15h30             Libre 

Vendredi 16/10/2015, 15h – 19h. Session 5 

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Modérateurs :             Thomas Mercher – Olivier Hérault 

15h30 - 16h15             Carmen Garrido (INSERM UMR866, Université de Bourgogne, Dijon). 

HspPathies: role of HSP70 in erythropoietic disorders  

16h15 - 16h30             Guillaume Giraud (Erasmus Medical Center, Rotterdam, Pays-Bas) 

Fli-1 and the Ldb1 complex: A group of friends playing together during megakaryopoiesis and leukemia  

16h30 - 16h45             Lucie Laplane (INSERM U1170, IGR, Villejuif) 

CSC and Clonal Evolution, an Epistemological Investigation 

16h45 - 17h             Pause 

17h00 - 17h15             David Garrick (INSERM U1126, Saint Louis) 

miR-125b-SUV39H1 pathway regulates heterochromatin and B lymphoid differentiation of human HSC with age  

17h15 - 17h30             Cyril Esnault (IGMM, UMR5535 CNRS, Montpellier) 

A chromatin modification cascade set the Ras-dependent immediate transcriptional program  

17h30 – 18h15              Brian J Huntly (CIMR, Cambridge University, Cambridge) 

Epigenetic dysfunction in haematological malignancies   

18h15 - 19h             AG  

20h             Dîner  

21h            Soirée    

Samedi 17/10/2015, 8h30 – 11h. Session 6 

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Modérateurs :             Michele Goodhardt – Patrice Dubreuil 

8h30 – 9h15             Ido Amit (Weizmann Institute of Science, Rehovot, Israel) 

Shaping the blood: Lessons from chromatin and single cell RNA-seq dynamics  

9h15 - 9h30             Coralie Hoareau-Aveilla (INSERM UMR1037 CRCT, Toulouse) 

Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK-positive cell growth  

9h30 - 9h45             Enguerran Mouly (INSERM U1170, IGR, Villejuif) 

Tet2 deficiency in mice a new model of CLL-like disease development 

9h45- 10h             Pause  

10h – 10h15             Isabelle Plo (INSERM U1170, IGR, Villejuif) 

Germline duplication of ATG2B and GSKIP predisposes to familial MPN and myeloid malignancies  

10h15- 11h             Bertrand Nadel (CIML, Marseille, France) 

Site- and allele-specific polycomb dysregulation in T-cell leukaemia  

 11h15 – 11h30           Remise des Prix 

                                       Fin du congrès